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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

However, there are many unusual symptoms associated with vitamin B12 deficiency, and most will disappear after taking vitamin B12 long enough to get the stores up to a normal amount and have maintained stable levels of vitamin B12

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This process cant happen when your immune system blocks your intrinsic factor